| Identification | Back Directory | [Name]
Endoxifen (E-isomer hydrochloride) | [CAS]
1197194-61-8 | [Synonyms]
E-ENDOXIFEN
Endoxifen E-isomer HCl
E-ENDOXIFEN HYDROCHLORIDE
Endoxifen E-isomer hydrochL
Endoxifen (E-isomer hydrochloride) | [Molecular Formula]
C25H28ClNO2 | [MDL Number]
MFCD29924733 | [MOL File]
1197194-61-8.mol | [Molecular Weight]
409.95 |
| Hazard Information | Back Directory | [Description]
Endoxifen E-isomer is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). | [Uses]
Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects[1][2]. | [References]
[1] Elkins P, et, al. Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC?MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9. DOI:10.1016/j.jpba.2013.07.010
[2] Zheng Y, et, al. Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. Drug Metab Dispos. 2007 Oct;35(10):1942-8. DOI:10.1124/dmd.107.016279 |
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