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1197300-24-5

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1197300-24-5 Structure

1197300-24-5 Structure
IdentificationBack Directory
[Name]

4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
[CAS]

1197300-24-5
[Synonyms]

TGR5
CCDC
CS-1017
MDK00245
TGR5 Receptor Agonist
CCDC(TGR5-Receptor-Agonist)
TGR5 Receptor Agonist, >=98%
BENZYL (4-CHLORO-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETATE
3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-4-IsoxazolecarboxaMide
3-(2-CHLOROPHENYL)-N-(4-CHLOROPHENYL)-N,5-DIMETHYLISOXAZOLE-4-CARBOXAMIDE
4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide
3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide TGR5
TGR5 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
[EINECS(EC#)]

200-256-5
[Molecular Formula]

C18H14Cl2N2O2
[MDL Number]

MFCD17169972
[MOL File]

1197300-24-5.mol
[Molecular Weight]

361.22
Chemical PropertiesBack Directory
[Boiling point ]

541.8±50.0 °C(Predicted)
[density ]

1.346±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 30 mg/ml
[form ]

A crystalline solid
[pka]

-0.52±0.50(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H332-H335
[Precautionary statements ]

P261-P280-P305+P351+P338
Hazard InformationBack Directory
[Description]

TGR5 receptor agonist is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50s = 31.6-158.5 nM in cell-based assays). It stimulates cAMP formation in HEK293 cells expressing TGR5 (EC50 = 2.3 pM). TGR5 receptor agonist (1 mg/kg) increases glucagon-like peptide 1 (GLP-1) secretion and decreases glucose levels in the hepatic portal vein in dogs when administered in combination with glucose. It also inhibits the cytochrome P450 (CYP) isozymes CYP2C19 and CYP3A4 (IC50s = 316.2 and 1,259 nM, respectively).
Spectrum DetailBack Directory
[Spectrum Detail]

4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-(1197300-24-5)1HNMR
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