| Identification | Back Directory | [Name]
3-(1-METHYLPIPERIDIN-4-YL)-1H-INDOL-5-OL MALEATE | [CAS]
1197333-54-2 | [Synonyms]
BRL 54443 MALEATE
BRL 54443 maleate salt
3-(1-METHYLPIPERIDIN-4-YL)-1H-INDOL-5-OL MALEATE
3-(1-Methylpiperidin-4-yl)-1H-indol-5-ol maleate salt
1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-, (2Z)-2-butenedioate (1:1) | [Molecular Formula]
C18H22N2O5 | [MDL Number]
MFCD01860866 | [MOL File]
1197333-54-2.mol | [Molecular Weight]
346.38 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: 50 mg/mL | [form ]
solid | [color ]
white | [Water Solubility ]
H2O: 50mg/mL | [InChI]
1S/C14H18N2O.C4H4O4/c1-16-6-4-10(5-7-16)13-9-15-14-3-2-11(17)8-12(13)14;5-3(6)1-2-4(7)8/h2-3,8-10,15,17H,4-7H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1- | [InChIKey]
INGCLXPSKXSYND-BTJKTKAUSA-N | [SMILES]
OC(=O)\C=C/C(O)=O.CN1CCC(CC1)c2c[nH]c3ccc(O)cc23 |
| Hazard Information | Back Directory | [Uses]
BRL 54443 Maleate Salt can be used in pharmacological activity and biological study of forskolin-free cAMP assay for Gi-coupled receptors. | [Biological Activity]
Potent 5-HT1E/1F serotonin receptor agonist. | [in vivo]
Reduction of flinching was considered as antinociception. Ipsilateral, but not contralateral, peripheral administration of BRL54443 (5-HT(1E/1F); 3-300 microg/paw) significantly reduced formalin-induced flinching in rats[3].
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