| Identification | Back Directory | [Name]
RO 04-6790 hydrochloride | [CAS]
1197333-95-1 | [Synonyms]
RO 04-6790 hydrochloride
Ro 04 6790 dihydrochloride,Ro 046790 dihydrochloride | [Molecular Formula]
C12H18Cl2N6O2S | [MDL Number]
MFCD14525468 | [MOL File]
1197333-95-1.mol | [Molecular Weight]
381.281 |
| Hazard Information | Back Directory | [Uses]
Ro 04-6790 dihydrochloride is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 dihydrochloride has no affinity at other receptors[1]. | [References]
[1] A J Sleight, et al. Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors. Br J Pharmacol. 1998 Jun;124(3):556-62. DOI:10.1038/sj.bjp.0701851
[2] Sudabeh Shirazi-Southall, et al. Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology. 2002 May;26(5):583-94. DOI:10.1016/S0893-133X(01)00400-6 |
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