| Identification | Back Directory | [Name]
BMS-819881 | [CAS]
1197420-05-5 | [Synonyms]
BMS-819881
BMS819881,BMS 819881
Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[4-[(2R)-2-cyclopropyl-2-hydroxyethoxy]-3-methoxyphenyl]- | [Molecular Formula]
C24H21ClN2O4S | [MDL Number]
MFCD28386209 | [MOL File]
1197420-05-5.mol | [Molecular Weight]
468.95 |
| Hazard Information | Back Directory | [Uses]
BMS 819881, is a potent and highly selective MCHR1 functional antagonist. It has how shown high selectivity towards CYP3A4 activity with an EC50 of 13 μM. | [in vivo]
BMS-819881 has moderate terminal elimination half-life (t1/2=5.7 h, 32±8 h, and 14±3 h for rat (1 mg/kg, iv), dog (1 mg/kg, iv), and cynomologous monkey (1 mg/kg, iv))[1]. | [IC 50]
rat MCHR1: 7 nM (Ki); CYP3A4: 13 μM (EC50) |
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