| Identification | Back Directory | [Name]
IFLAB-BB F1950-0211 | [CAS]
1198098-03-1 | [Synonyms]
WAY-119064
IFLAB-BB F1950-0211
(5Z)-2-Amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one
(5Z)-5-(3,4-dimethoxybenzylidene)-2-imino-1,3-thiazolidin-4-one | [Molecular Formula]
C12H12N2O3S | [MDL Number]
MFCD05885488 | [MOL File]
1198098-03-1.mol | [Molecular Weight]
264.3 |
| Chemical Properties | Back Directory | [Boiling point ]
454.8±55.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 13 mg/mL (49.19 mM);Ethanol: Insoluble | [form ]
Solid | [pka]
-0.59±0.20(Predicted) | [color ]
Light yellow to yellow | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Uses]
GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease[1]. | [Biological Activity]
WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM. | [IC 50]
GSK-3β: 80.5 nM (IC50) | [References]
[1] Arfeen M, et al. Eur J Med Chem. 2016 Oct 4;121:727-736. |
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