| Identification | Back Directory | [Name]
SodiuM Channel inhibitor 1 | [CAS]
1198117-23-5 | [Synonyms]
CS-1478
SodiuM Channel inhibitor 1
7-Fluoro-2,3-dihydro-3-oxo-2-[2-(2-pyridinyl)ethyl]-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide
1H-Isoindole-1-carboxamide, 7-fluoro-2,3-dihydro-3-oxo-2-[2-(2-pyridinyl)ethyl]-N-[[4-(trifluoromethoxy)phenyl]methyl]- | [Molecular Formula]
C24H19F4N3O3 | [MOL File]
1198117-23-5.mol | [Molecular Weight]
473.42 |
| Chemical Properties | Back Directory | [Boiling point ]
629.6±55.0 °C(Predicted) | [density ]
1.380±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
13.07±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.
IC50 Value: 0.16 uM ( Na v1.7, V hold-90mV); 0.41 uM (Na v1.7, V hold-90mV) [1]
Target: Na v1.7
Sodium Channel inhibitor1 demonstrated concentration-dependent efficacy in preclinical behavioral pain models. | [References]
[1] Macsari I, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80. DOI:10.1021/jm300623u |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
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