| Identification | Back Directory | [Name]
Acetic acid, 2-[[(3S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-pyrrolidinyl]oxy]- | [CAS]
1198180-03-8 | [Synonyms]
RBP4 inhibitor 1
Acetic acid, 2-[[(3S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-pyrrolidinyl]oxy]- | [Molecular Formula]
C14H13F6NO3 | [MOL File]
1198180-03-8.mol | [Molecular Weight]
357.25 |
| Chemical Properties | Back Directory | [Boiling point ]
419.7±45.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.42±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
RBP4 inhibitor 1 (compound 43b) is a potent and orally active retinol-binding protein 4 (RBP4) inhibitor with IC50s of 28 nM and 110 nM for human and mouse RBP4. RBP4 inhibitor 1 has a potent and long-lasting blood RBP4-level-reducing effect in mice[1]. | [References]
[1] Shinji Nakamura, et al. Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers. Bioorg Med Chem. 2022 Jan 15;54:116553. DOI:10.1016/j.bmc.2021.116553 |
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