| Identification | Back Directory | [Name]
5H-Imidazo[1,2-c][1,3]benzoxazine-5-thione, 2-methyl-3-propyl- | [CAS]
1199944-04-1 | [Synonyms]
MV1035
NaV1.2/1.6 channel blocker-1
5H-Imidazo[1,2-c][1,3]benzoxazine-5-thione, 2-methyl-3-propyl- | [Molecular Formula]
C14H14N2OS | [MOL File]
1199944-04-1.mol | [Molecular Weight]
258.34 |
| Chemical Properties | Back Directory | [Melting point ]
98-100 °C | [Boiling point ]
481.0±48.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
1.92±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV1.2, respectively. NaV1.2/1.6 channel blocker-1 can be used for the research of generalized epilepsy[1]. | [IC 50]
rNaV1.6: 9.8 μM (IC50); hNaV1.2: 24.4 μM (IC50) | [References]
[1] Rivara M, et, al. Biological Evaluation of Imidazobenzoxazines, Imidazobenzoxazin-5-ones and Imidazobenzoxazin-5-thiones as Sodium Channel Blockers. Letters in Drug Design & Discovery, 2014, 11, 90-97. |
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