| Identification | Back Directory | [Name]
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine | [CAS]
120014-07-5 | [Synonyms]
Donepezil-013
Donepezil-013-Z
Dehydro Donepezi
Dehydro Donepezil
Donepezil USP RC A
Donepezil Impurity O
Donepezil Impurity 17
Donepezil related compound
1-Benzyl-4-(5,6-dimethoxy-1-ox
2-[(1-Benzylpiperidin-4-yl)methylen
Dehydro Donepezil (Donepezil Impurity)
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-
Donepezil related coMpound (E/Z Mixture)
Donepezil Dehydro Impurity (E/Z mixture)
1-Benzyl-4-(5,6-diMethoxy-1-oxoindan-2-ylindeneMet
2-[(1-benzyl-4-piperidyl)methyleen]-5,6-dimethoxyindan-1-on
2-(1-Benzylpiperidin-4-ylmethylidene)-5,6-dimethoxyindan-1-one
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperi...
1-benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine
2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE
2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydroinden-1-one
2-[(1-Benzylpiperidin-4-yl)methylene]-2,3-dihydro-5,6-dimethoxyinden-1-one
2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one
1-Benzyl-4-[(1,3-dihydro-5,6-dimethoxy-1-oxo-2H-inden-2-ylidene)methyl]piperidine
(E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one 97%
1-Benzyl-4-[(5,6-diMethoxy-1-oxoindan-2-ylidene)Methyl]piperidine
(Donepezil IMpurity)
2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one
Donepezil impurity 16/1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
1H-Inden-1-one, 2,3-dihydro- 5,6-diMethoxy-2-[[1-( phenylMethyl)-4-piperidinyl] Methylene]-
1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine
DISCONTINUED. Please see D229775 | [EINECS(EC#)]
601-652-4 | [Molecular Formula]
C24H27NO3 | [MDL Number]
MFCD08693144 | [MOL File]
120014-07-5.mol | [Molecular Weight]
377.48 |
| Chemical Properties | Back Directory | [Melting point ]
176-178°C | [Boiling point ]
542.8±50.0 °C(Predicted) | [density ]
1.209±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
8.03±0.10(Predicted) | [Appearance]
White to light yellow Solid |
| Questions And Answer | Back Directory | [Synthesis]
A solution of 5,6-dimethoxy-indanone (19 g, 0.10 mol) in methanol (8 mL) is stirred under inert
atmosphere at room temperature. Slowly add NaOH flakes
(12.8 g, 0.32 mol) followed by N-benzyl-piperidine-4-carboxaldehyde (20.2 g, 0.10 mol) to the reaction mixture. The
mixture was stirred at room temperature for 3 h and progress
of the reaction was monitored by TLC (hexane:ethyl acetate;
1:1). Once the reaction is complete, the solid formed was
filtered, washed with 5 % acetic acid and then with methanol
and dried. The obtained solid (34 g) was taken into a round
bottom flask and refluxed with DMF (50 mL). Gradually cooled
to room temperature and stirred for 2 h, filtered the solid
formed, wash with chilled methanol to afford a pale yellow
crystalline solid 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine (32.0 g, 84 %); m.p.: 175-177 °C.
 |
| Hazard Information | Back Directory | [Uses]
An impurity of Donepezil (D531750); an intermediate as an anti-Alzheimer's agent. | [Uses]
An impurity of Donepezil; an intermediate as an anti-Alzheimer agent. | [References]
[1] Patent: US2009/253746, 2009, A1. Location in patent: Page/Page column 3
[2] Patent: EP1911745, 2008, A1. Location in patent: Page/Page column 11-12
[3] Patent: EP1911745, 2008, A1. Location in patent: Page/Page column 10
[4] Patent: EP1911745, 2008, A1. Location in patent: Page/Page column 14
[5] Organic Process Research and Development, 2008, vol. 12, # 4, p. 731 - 735 |
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Sinfachem Limited.
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http://www.sinfachem.com |
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