| Identification | Back Directory | [Name]
thrazarine | [CAS]
120128-14-5 | [Synonyms]
FR-900840
thrazarine
Antibiotic FR-900840
O-[(R)-2-Diazo-3-hydroxy-1-oxobutyl]-L-serine | [Molecular Formula]
C7H11N3O5 | [MDL Number]
MFCD00873761 | [MOL File]
120128-14-5.mol | [Molecular Weight]
217.18 |
| Hazard Information | Back Directory | [Uses]
Thrazarine (FR 900840) is an oncology antibiotic that can be produced by Streptomyces coerulescens MH802-fF5. Thrazarine directly inhibits DNA synthesis and tumor cell growth. Thrazarine can specifically induce lysis of tumor cells co-cultured with non-activated macrophages. Thrazarine is used in cancer research[1]. | [References]
[1] Kameyama T, et al. Thrazarine, a new antitumor antibiotic. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo). 1988 Nov;41(11):1561-7. DOI:10.7164/antibiotics.41.1561 |
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