| Identification | Back Directory | [Name]
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide | [CAS]
1201652-50-7 | [Synonyms]
2-{[(5-methyl-2-thienyl)methylene]amino} 2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide (E)-2-(((5-Methylthiophen-2-yl)methylene)amino)-N-phenylbenzamide Benzamide, 2-[(E)-[(5-methyl-2-thienyl)methylene]amino]-N-phenyl- 2-{[(E)-(5-methylthiophen-2-yl)methylidene]amino}-N-phenylbenzamide LC3-II,inhibit,Inhibitor,Retro-2,retrograde,Shiga-like,Golgi,Filovirus,toxins,Retro2,GFP-LC3,trafficking,Autophagy,Parasite | [Molecular Formula]
C19H16N2OS | [MDL Number]
MFCD01042512 | [MOL File]
1201652-50-7.mol | [Molecular Weight]
320.41 |
| Chemical Properties | Back Directory | [Boiling point ]
461.9±40.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.20±0.70(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy[1][2][3]. | [in vivo]
Retro-2 (2-200 mg/kg; i.p; daily; for 21 days) treatment clearly protects from lethal nasal exposure to ricin in mice. 200 mg/kg of Retro-2 fully protects mice against ricin challenge[1]. | Animal Model: | Female Balb/c mice (Pathogen-free 6-week-old) injected with ricin (2 μg/kg)[1] | | Dosage: | 2 mg/kg, 10 mg/kg, 20 mg/kg, 200 mg/kg | | Administration: | Intraperitoneal injection; daily; for 21 days | | Result: | Protected mice against ricin challenge.
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| [IC 50]
Leishmania; EBOV | [References]
[1] Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42. DOI:10.1016/j.cell.2010.01.043 [2] Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464. DOI:10.3389/fcell.2020.00464 [3] Olena Shtanko, et al. Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection. Antiviral Res. 2018 Jan;149:154-163. DOI:10.1016/j.antiviral.2017.11.016 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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