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1201652-50-7

1201652-50-7 Structure

1201652-50-7 Structure
IdentificationBack Directory
[Name]

2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide
[CAS]

1201652-50-7
[Synonyms]

2-{[(5-methyl-2-thienyl)methylene]amino}
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide
(E)-2-(((5-Methylthiophen-2-yl)methylene)amino)-N-phenylbenzamide
Benzamide, 2-[(E)-[(5-methyl-2-thienyl)methylene]amino]-N-phenyl-
2-{[(E)-(5-methylthiophen-2-yl)methylidene]amino}-N-phenylbenzamide
LC3-II,inhibit,Inhibitor,Retro-2,retrograde,Shiga-like,Golgi,Filovirus,toxins,Retro2,GFP-LC3,trafficking,Autophagy,Parasite
[Molecular Formula]

C19H16N2OS
[MDL Number]

MFCD01042512
[MOL File]

1201652-50-7.mol
[Molecular Weight]

320.41
Chemical PropertiesBack Directory
[Boiling point ]

461.9±40.0 °C(Predicted)
[density ]

1.17±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

13.20±0.70(Predicted)
[color ]

White to yellow
Hazard InformationBack Directory
[Uses]

Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy[1][2][3].
[in vivo]

Retro-2 (2-200 mg/kg; i.p; daily; for 21 days) treatment clearly protects from lethal nasal exposure to ricin in mice. 200 mg/kg of Retro-2 fully protects mice against ricin challenge[1].

Animal Model:Female Balb/c mice (Pathogen-free 6-week-old) injected with ricin (2 μg/kg)[1]
Dosage:2 mg/kg, 10 mg/kg, 20 mg/kg, 200 mg/kg
Administration:Intraperitoneal injection; daily; for 21 days
Result:Protected mice against ricin challenge.
[IC 50]

Leishmania; EBOV
[References]

[1] Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42. DOI:10.1016/j.cell.2010.01.043
[2] Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464. DOI:10.3389/fcell.2020.00464
[3] Olena Shtanko, et al. Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection. Antiviral Res. 2018 Jan;149:154-163. DOI:10.1016/j.antiviral.2017.11.016
Spectrum DetailBack Directory
[Spectrum Detail]

2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide(1201652-50-7)1HNMR
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