| Identification | Back Directory | [Name]
BI 167107
(BI167107) | [CAS]
1202235-68-4 | [Synonyms]
BI-167107
BI 167107
(BI167107)
5-hydroxy-8-(1-hydroxy-2-((2-methyl-1-(o-tolyl)propan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
2H-1,4-Benzoxazin-3(4H)-one, 8-[2-[[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino]-1-hydroxyethyl]-5-hydroxy- | [Molecular Formula]
C21H26N2O4 | [MOL File]
1202235-68-4.mol | [Molecular Weight]
370.44 |
| Chemical Properties | Back Directory | [Boiling point ]
621.7±55.0 °C(Predicted) | [density ]
1.229±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 75 mg/mL (202.46 mM) | [form ]
Solid | [pka]
8.52±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BI-167107 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM[1]. | [Biological Activity]
BI-167107 is a high affinity β2 adrenergic receptor (β2AR) full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM. | [in vitro]
Compared to other βAR ligands, BI-167107 displays nanomolar affinities and slow off-rates. | [target]
| [References]
[1] Rasmussen SG, et al. Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature. 2011 Jan 13;469(7329):175-80. DOI:10.1038/nature09648 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
| Company Name: |
MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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