| Identification | Back Directory | [Name]
CNX-774 | [CAS]
1202759-32-7 | [Synonyms]
CS-946
CNX-774
CNX-774(97 %)
CNX774; CNX 774
CNX-774 USP/EP/BP
4-(4-((4-(acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
4-(4-((4-((3-Acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamid
4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide
4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
2-Pyridinecarboxamide, 4-[4-[[5-fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-
4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide CNX-774 | [Molecular Formula]
C26H22FN7O3 | [MDL Number]
MFCD26405992 | [MOL File]
1202759-32-7.mol | [Molecular Weight]
499.496 |
| Chemical Properties | Back Directory | [density ]
1.383±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20° C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
13.22±0.70(Predicted) | [color ]
Light yellow to yellow | [CAS DataBase Reference]
1202759-32-7 |
| Hazard Information | Back Directory | [Uses]
CNX-774 is an irreversible, orally active, and highly selective inhibitor of Bruton’s tyrosine kinase (BTK) and can be used for the treatment of rheumatoid arthritis (RA). | [Biological Activity]
cnx-774 is an orally active and selective inhibitor of btk with ic50 value of <1 nm.bruton’s tyrosine kinase (btk) is an important enzyme in the b-cell antigen receptor (bcr) signaling pathway and also plays an important role in mast cell activation and b cell maturation.cnx-774 is an orally active, irreversible and selective btk inhibitor with ic50 value of <1 nm. cnx-774 formed covalent bond with the cys481 residue within the atp binding site of btk. in cellular assays, cnx-774 inhibited btk with ic50 values of 1-10 nm [1]. | [in vivo]
CNX-774 is stable and non-reactive in fresh human and rat whole blood and does not covalently bond to any of the mid-level abundance human plasma proteins[1].
CNX-774 demonstrates potent inhibitory activity towards the intended target, Btk, while achieving remarkable specificity in a variety of assays designed to assess off-target reactivity towards abundant cellular thiols and blood proteins[1].
| [storage]
Store at -20° C | [References]
[1]. akinleye a, chen y, mukhi n, et al. ibrutinib and novel btk inhibitors in clinical development. j hematol oncol, 2013, 6: 59. |
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| Company Name: |
LETOPHARM LIMITED
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| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
SPIRO PHARMA
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| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
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