| Identification | Back Directory | [Name]
PU-H71 Hydrate | [CAS]
1202865-65-3 | [Synonyms]
CS-106
PU-H71 Hydrate
PU-H71 Hydrate(1:x)
6-AMino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-Methylethyl)-9H-purine-9-propanaMine hydrate | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C18H21IN6O2S | [MDL Number]
MFCD17215935 | [MOL File]
1202865-65-3.mol | [Molecular Weight]
512.368 |
| Hazard Information | Back Directory | [Uses]
PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM). Hsp90 plays a critical role in modulating the activity of many cell signaling proteins and are an attractive target for anti-cancer therapeutics. Studies indicate that Hsp90 inhibitors may serve as potent | [Uses]
PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM). Hsp90 plays a critical role in modulating the activity of many cell signaling proteins and are an attractive target for anti-cancer therapeutics. Studies indicate that Hsp90 inhibitors may serve as potential anti-Parkinson′s disease. | [References]
[1] HUAZHONG HE. Identification of Potent Water Soluble Purine-Scaffold Inhibitors of the Heat Shock Protein 90[J]. Journal of Medicinal Chemistry, 2005, 49 1: 381-390. DOI: 10.1021/jm0508078
[2] SAAD Z USMANI. The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.[J]. Journal of Hematology & Oncology, 2010, 3: 40. DOI: 10.1186/1756-8722-3-40
[3] ELOISI CALDAS-LOPES. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 20: 8368-8373. DOI: 10.1073/pnas.0903392106 |
|
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|