| Identification | Back Directory | [Name]
DASA-58 | [CAS]
1203494-49-8 | [Synonyms]
DASA-58
CS-1563
DASA58; DASA 58
3-[[4-[(2,3-Dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]benzenamine
Benzenamine, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]- | [Molecular Formula]
C19H23N3O6S2 | [MDL Number]
MFCD29472280 | [MOL File]
1203494-49-8.mol | [Molecular Weight]
453.53 |
| Chemical Properties | Back Directory | [Boiling point ]
681.5±65.0 °C(Predicted) | [density ]
1.453±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
insoluble in EtOH; insoluble in H2O; ≥127.2 mg/mL in DMSO | [form ]
solid | [pka]
3.35±0.10(Predicted) | [color ]
White to off-white | [InChI]
1S/C19H23N3O6S2/c20-15-3-1-4-16(13-15)29(23,24)21-7-2-8-22(10-9-21)30(25,26)17-5-6-18-19(14-17)28-12-11-27-18/h1,3-6,13-14H,2,7-12,20H2 | [InChIKey]
GMHIOMMKSMSRLY-UHFFFAOYSA-N | [SMILES]
NC1=CC=CC(S(N2CCN(S(C3=CC=C(OCCO4)C4=C3)(=O)=O)CCC2)(=O)=O)=C1 |
| Hazard Information | Back Directory | [Description]
DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 μM in cells). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins. Through its effects on PKM2, DASA-58 blocks the induction of HIF-1α by lipopolysaccharide in bone marrow-derived macrophages, suppressing the expression of several HIF-1α-dependent targets, including IL-1β. It also impairs metastatic dissemination of prostate cancer PCa cells in SCID mice. | [Uses]
DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer[1]. | [Definition]
ChEBI: 3-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl]aniline is a member of benzenes and a sulfonamide. | [References]
[1]. anastasiou d, yu y, israelsen wj, et al. pyruvate kinase m2 activators promote tetramer formation and suppress tumorigenesis. nature chemical biology, 2012, 8(10): 839-847. |
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D&C Chemicals
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+86-21-58447131 |
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