| Identification | Back Directory | [Name]
Urease-IN-16 | [CAS]
1203704-26-0 | [Synonyms]
Urease-IN-16
5-Pyrimidinecarboxylic acid, 4-(3-boronophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxo-, 5-ethyl ester | [Molecular Formula]
C14H17BN2O4S | [MOL File]
1203704-26-0.mol | [Molecular Weight]
320.17 |
| Chemical Properties | Back Directory | [Melting point ]
170-172 °C | [Boiling point ]
503.251±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.355±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
8.192±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
Urease-IN-16 (compound 4e) is a urease inhibitor, with an IC50 value of 132 μmol/L. Urease-IN-16 can coordinate with the nickel atom through the oxygen atoms of carbonyl or boronic acid groups. Urease-IN-16 shows great potential as an additive in the development of efficient fertilizers and medical applications[1]. | [References]
[1] Morais Costa NE, et al. Synthesis and anti-ureolitic activity of Biginelli adducts derived from formylphenyl boronic acids. Bioorg Chem. 2024 Nov;152:107735. DOI:10.1016/j.bioorg.2024.107735 |
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