| Identification | Back Directory | [Name]
MN(III) PROTOPORPHYRIN IX CHLORIDE | [CAS]
120389-54-0 | [Synonyms]
BJLYQWVPQKTSMI-UHFFFAOYSA-K
MN(III) PROTOPORPHYRIN IX CHLORIDE
8,13-BIS(VINYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID MANGANESE(III) CHLORIDE
Manganate(2-),chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)- | [Molecular Formula]
C34H32ClMnN4O4 | [MDL Number]
MFCD00216788 | [MOL File]
120389-54-0.mol | [Molecular Weight]
651.03 |
| Hazard Information | Back Directory | [Uses]
Mn(III) protoporphyrin IX chloride is a metalloporphyrin. It induces mRNA expression of the genes encoding δ-aminolevulinate synthase and heme oxygenase (HO), enzymes that catalyze the rate-limiting steps of heme biosynthesis and degradation, respectively, in chick embryo liver cells when used at a concentration of 10 μM. Mn(III) protoporphyrin IX chloride-containing nanobialys have been used in magnetic resonance imaging (MRI) of fibrin clots in vitro. It has also been used in the synthesis of Mn(III) protoporphyrin IX-6(7)-glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate with microperoxidase activity. | [References]
[1] Cable, et al. Differential effects of metalloporphyrins on messenger RNA levels of δ-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells. J. Clin. Invest. 94(2), 649-654 (1994). |
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