| Identification | Back Directory | [Name]
GEA 857 | [CAS]
120493-42-7 | [Synonyms]
GEA 857
L-Valine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester | [Molecular Formula]
C15H22ClNO2 | [MDL Number]
MFCD00913982 | [MOL File]
120493-42-7.mol | [Molecular Weight]
283.79 |
| Hazard Information | Back Directory | [Description]
Gea 857 is a putative blocker of potassium conductance. | [Uses]
GEA 857 is a structural analog of the Serotonin (HY-B1473A) uptake blocker Alaproclate (HY-164011). GEA 857 enhances responses induced by muscarinic receptor agonists by inhibiting certain calcium-dependent potassium channels on membranes, a blockade that can enhance or prolong the muscarinic cholinergic effects. GEA 857 can be used in research on neurodegenerative diseases[1]. | [References]
[1] ?gren, et al. GEA 857, A Putative Blocker of Potassium Conductance, Enhances Muscarinic Agonist‐Evoked Responses: Dissociation from an Action on 5‐HT Mechanisms. Pharmacology & toxicology 71.2 (1992): 112-119. DOI:10.1111/j.1600-0773.1992.tb00529.x |
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