| Chemical Properties | Back Directory | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear (Warmed) | [form ]
powder | [color ]
white to beige | [InChIKey]
GVPVVOSNDUAUKM-MRIOYIRHNA-N | [SMILES]
C([C@H](N)C(=O)O)CCNC(N)=N.C([C@H]1CCC2C3=CC(OCC4C=CC(C5CCCC5)=C(C(F)(F)F)C=4)=CC=C3NC1=2)C(=O)O |&1:1,13,r| |
| Hazard Information | Back Directory | [Uses]
Etrasimod arginine is an orally available S1P receptor modulator that is a potent full agonist of the S1P1 receptor and has partial agonist activity at S1P4. Etrasimod arginine reduces inflammation in a CD4+CD45RBhigh T cell-transferred mouse colitis model[1]. | [Biological Activity]
Etrasimod arginine is an orally availablepotentand selective agonist of Sphingosine-1-Phosphate Receptors 1 (S1PR1). Alsoit acts as a partial agonist of S1PR4,5. Etrasimod arginine induces reductions in lymphocyte counts in mice. It is acting as immunosuppressive agents. | [References]
[1] Etrasimod arginine. Sphingosine-1-phosphate receptor 1 (S1P1 receptor) agonist, Treatment of ulcerative colitis |
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