| Identification | Back Directory | [Name]
CILANSETRON | [CAS]
120635-47-4 | [Synonyms]
5-HT3 antagonist 3
Imidazol-1-yl compound 1
10-((2-methyl-1H-imidazol-1-yl)methyl)-5,6,9,10-tetrahydro-4H-pyrido[3,2,1-jk]carbazol-11(8H)-one
4H-Pyrido[3,2,1-jk]carbazol-11(8H)-one, 5,6,9,10-tetrahydro-10-[(2-methyl-1H-imidazol-1-yl)methyl]- | [Molecular Formula]
C20H21N3O | [MDL Number]
MFCD00866227 | [MOL File]
120635-47-4.mol | [Molecular Weight]
319.4 |
| Chemical Properties | Back Directory | [Boiling point ]
600.6±50.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
7.50±0.33(Predicted) |
| Hazard Information | Back Directory | [Uses]
5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. 5-HT3 antagonist 3 binds to 5-HT3 receptors in rat brain cortical membranes with Ki of 0.25 nM[1]. | [IC 50]
5-HT3 Receptor: 0.25 nM (Ki) | [storage]
Store at -20°C | [References]
[1] van Wijngaarden I, et al. Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. J Med Chem. 1993 Nov 12;36(23):3693-9. DOI:10.1021/jm00075a026 |
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