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1206524-85-7

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1206524-85-7 Structure

1206524-85-7 Structure
IdentificationBack Directory
[Name]

MK-5172
[CAS]

1206524-85-7
[Synonyms]

MK-5172
EOS-61017
UNII-RU4QU6O6X6
MK-5172 intermidiate
Grazoprevir Intermediate 5
(33R,35S,91R,92R,5S)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxylicacid
(1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
(1aR,5S,8R,10S,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
(1aR,5S,8S,10R,22aR)-5-(1,1-Dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-diMethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-Methoxy-3,6-dioxo-,(1aR,5S,8S,10R,22aR)-
[EINECS(EC#)]

943-551-0
[Molecular Formula]

C29H38N4O7
[MDL Number]

MFCD22741510
[MOL File]

1206524-85-7.mol
[Molecular Weight]

554.63
Chemical PropertiesBack Directory
[Melting point ]

180-185oC
[Boiling point ]

825.0±65.0 °C(Predicted)
[density ]

1.33
[storage temp. ]

Sealed in dry,Store in freezer, under -20°C
[solubility ]

Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol
[form ]

Solid
[pka]

3.23±0.40(Predicted)
[color ]

White to Off-White
[Stability:]

Hygroscopic
[InChIKey]

IVROMYPOGKZNLP-FDOFPDFBSA-N
[SMILES]

N1C2C(=CC=C(OC)C=2)N=C2CCCCC[C@]3([H])C[C@@]3([H])OC(=O)N[C@@H](C(C)(C)C)C(=O)N3C[C@]([H])(OC=12)C[C@H]3C(O)=O
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[REACH Registrations]

Active
Hazard InformationBack Directory
[Uses]

MK-?5172 is a selective inhibitor of hepatitis C virus NS3?/4a protease with broad activity across genotypes and resistant variants.
[Advantages]

MK-5172 has a higher barrier to resistance than first-generation protease inhibitors and is active against most variants associated with resistance to first-generation protease inhibitors. Tolerability and safety profile are good.
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