| Identification | Back Directory | [Name]
Benzenepropanoic acid, 4-[2-(2,6-dichloro-4-pyridinyl)ethynyl]- | [CAS]
1206629-08-4 | [Synonyms]
TUG-499
Benzenepropanoic acid, 4-[2-(2,6-dichloro-4-pyridinyl)ethynyl]- | [Molecular Formula]
C16H11Cl2NO2 | [MOL File]
1206629-08-4.mol | [Molecular Weight]
320.17 |
| Chemical Properties | Back Directory | [Boiling point ]
522.2±50.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 100mg/mL, clear, colorless | [form ]
Solid | [pka]
4.49±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) (Free Fatty Acid Receptor) agonist with a pEC50 of 7.39. TUG-499 exhibits >100-fold selectivity over the related receptors FFA2, FFA3, and the nuclear receptor PPARγ and other diverse receptors, ion channels, and transporters. TUG-499 can be used for the research of type 2 diabetes[1]. TUG-499 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Elisabeth Christiansen, et al. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties. J Med Chem. 2011 Oct 13;54(19):6691-703. DOI:10.1021/jm2005699 |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|