| Identification | Back Directory | [Name]
1H-Pyrazolo[4,3-c]pyridine, 6-broMo- | [CAS]
1206973-12-7 | [Synonyms]
100715
6-BroMo-1H-pyrazolo[4,3-c...
6-broMo-Pyrazolo[4,3-c]pyridine
1H-Pyrazolo[4,3-c]pyridine, 6-broMo- | [Molecular Formula]
C6H4BrN3 | [MDL Number]
MFCD17010106 | [MOL File]
1206973-12-7.mol | [Molecular Weight]
198.02 |
| Chemical Properties | Back Directory | [density ]
1.894 | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder | [color ]
Yellow | [InChI]
InChI=1S/C6H4BrN3/c7-6-1-5-4(2-8-6)3-9-10-5/h1-3H,(H,9,10) | [InChIKey]
PGKALOYNTWMFKJ-UHFFFAOYSA-N | [SMILES]
C1=NC(Br)=CC2NN=CC1=2 |
| Hazard Information | Back Directory | [Uses]
6-Bromo-1H-pyrazolo[4,3-c]pyridine is a key synthetic building block that can be used to construct a variety of N1-substituted pyrazolo[4,3-c]pyridine frameworks. The bromine atom at the 6-position in its structure can participate in both copper-catalysed cross-coupling reactions and N-alkylation reactions with halogenated alkanes under basic conditions. These intermediates can also be utilised in the synthesis of PLK4 inhibitors via reactions such as palladium-catalysed C–H activation and nitro reduction[1].
| [Uses]
1H-Pyrazolo[4,3-c]pyridine, 6-broMo- is commonly used in proteomics and chemical research. | [References]
[1] Jeong*, J. W., Chang, T., and, Murray, J. M. (2025). Discovery of Potent, Selective and Efficacious Aminopyrazole Inhibitors of PLK4. Journal of Medicinal Chemistry, 68 23, 25198–25212. https://doi.org/10.1021/acs.jmedchem.5c02200
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