| Identification | Back Directory | [Name]
4-[(4S,5R)-4,5-bis(3,4-dichlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one | [CAS]
1207480-88-3 | [Synonyms]
Caylin 1,Caylin1
Caylin-1 Exclusive
4-[(4S,5R)-4,5-bis(3,4-dichlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
2-Piperazinone, 4-[[(4R,5S)-4,5-bis(3,4-dichlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel- | [Molecular Formula]
C30H28Cl4N4O4 | [MOL File]
1207480-88-3.mol | [Molecular Weight]
650.38 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2)(1:3): .25 mg/ml | [form ]
A crystalline solid | [pka]
14.17±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Caylin-1 is an inhibitor of MDM2 and an analog of Nutlin-3. Caylin-1 can bind to Bcl-XL and is used in multi-target anticancer research[1][2]. | [storage]
Store at -20°C | [References]
[1] Shin J S, et al. Structural insights into the dual-targeting mechanism of Nutlin-3[J]. Biochemical and Biophysical Research Communications, 2012, 420(1): 48-53. DOI:10.1016/j.bbrc.2012.02.113
[2] Li J, et al. A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53–MDM2 interaction[J]. Journal of biomolecular screening, 2011, 16(4): 450-456. DOI:10.1177/1087057111399191 |
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