| Identification | Back Directory | [Name]
1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro- | [CAS]
1207660-00-1 | [Synonyms]
HIT ID
Indophagolin
5-Bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)-1-(cyclopropanecarbonyl)indoline-6-sulfonamide
1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-
inhibit,formation,Inhibitor,Indophagolin,5-hydroxytryptamine Receptor,autophagosome,Serotonin Receptor,P2XRs,P2X Receptor,5-HT Receptor,membrane-bound,indoline-based,class,Autophagy | [Molecular Formula]
C19H15BrClF3N2O3S | [MDL Number]
MFCD14721653 | [MOL File]
1207660-00-1.mol | [Molecular Weight]
523.75 |
| Chemical Properties | Back Directory | [Boiling point ]
664.5±65.0 °C(Predicted) | [density ]
1.740±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO:250.0(Max Conc. mg/mL);477.33(Max Conc. mM) | [form ]
Solid | [pka]
6.84±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1]. | [IC 50]
P2X1: 2.4 μM (IC50); P2X4: 2.71 μM (IC50); P2Y11: 3.4 μM (IC50); P2X3: 3.49 μM (IC50); P2Y4: 4.89 μM (IC50); P2Y6: 15.4 μM (IC50); Autophagy: 140 nM (IC50); 5-HT6 Receptor: 1.0 μM (IC50) | [References]
[1] Carnero Corrales MA, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin [published online ahead of print, 2021 Mar 9]. Cell Chem Biol. 2021;S2451-9456(21)00102-1. DOI:10.1016/j.chembiol.2021.02.017 |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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