| Identification | Back Directory | [Name]
Broflanilide | [CAS]
1207727-04-5 | [Synonyms]
Broflanilide
N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-2-fluoro-3-((2-oxo-2-phenylethyl)amino)benzamide
Benzamide, 3-(benzoylmethylamino)-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluoro- | [Molecular Formula]
C25H14BrF11N2O2 | [MDL Number]
MFCD31657367 | [MOL File]
1207727-04-5.mol | [Molecular Weight]
663.28 |
| Hazard Information | Back Directory | [Description]
Broflanilide is an insecticide that is used to control chewing pests. It has a low aqueous solubility and is not considered to be highly volatile. In some situations it may be very persistent in soil and in water systems. Whilst it is highly toxic to honeybees, It generally tends to have a low to moderate toxicity to most other fauna and flora. It has a low oral mammalian toxicity and no other human health concerns have been identified. | [Uses]
Broflanilide is a pesticide for controlling animals and microbial pests such as unwanted insects. Broflanilide is a prominent insecticide because of it’s effective against pests with resistance to cyclodienes and fipronil. Broflanilide is metabolized to desmethyl-broflanilide that acts as a noncompetitive resistant-to-dieldrin (RDL) γ-aminobutyric acid (GABA) receptor antagonist. | [Definition]
ChEBI: Broflanilide is a benzamide obtained by formal condensation of the carboxy group of 3-[benzoyl(methyl)amino]-2-fluorobenzoic acid with the amino group of 2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)aniline. An insecticide that exhibits high larvicidal activity against Spodoptera litura and is effective against pests with resistance to cyclodienes and fipronil It has a role as an agrochemical and a GABA antagonist. It is a member of benzamides, a member of monofluorobenzenes, an organofluorine insecticide, a member of bromobenzenes and a member of (trifluoromethyl)benzenes. | [Production Methods]
Commercial broflanilide production relies on multi-step synthesis of its meta-diamide core, followed by controlled crystallisation and formulation into technical-grade material. Industrial routes mirror the patented improved processes, which assemble the brominated, perfluoroalkyl-substituted anilide and couple it with the fluorinated benzamide fragment, then purify and convert it into the desired crystalline form for stability and downstream formulation. | [Mechanism of action]
Metabolises to desmethyl-broflanilide which the acts as a noncompetitive resistant-to-dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor antagonist | [Pesticide Type]
Insecticide; Larvicide |
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