| Identification | Back Directory | [Name]
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile | [CAS]
1207836-10-9 | [Synonyms]
LOXO-292 intermediate
6-Bromo-4-methoxypyrazoL
o[1,5-a]pyridine-3-carbonitriL
6-bromo-4-methoxypyrazole[1,5-a]pyridine-3-carbonitrile
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-methoxy- | [EINECS(EC#)]
210-745-2 | [Molecular Formula]
C9H6BrN3O | [MDL Number]
MFCD27937916 | [MOL File]
1207836-10-9.mol | [Molecular Weight]
252.07 |
| Chemical Properties | Back Directory | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Solid | [pka]
-1.97±0.30(Predicted) | [InChI]
InChI=1S/C9H6BrN3O/c1-14-8-2-7(10)5-13-9(8)6(3-11)4-12-13/h2,4-5H,1H3 | [InChIKey]
JTEWRYBKHXGXHP-UHFFFAOYSA-N | [SMILES]
C12=C(C#N)C=NN1C=C(Br)C=C2OC |
| Hazard Information | Back Directory | [Description]
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a pharmaceutical intermediate ingredient for the preparation of Selpercatinib, indicated for the treatment of patients with advanced cancers who test positive for certain RETs. | [Uses]
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is an organic intermediate for laboratory R&D processes. | [Synthesis]
The DMF 10L solution of 2,4,6-trimethylbenzenesulfonic acid 3-bromo-5-methoxypyridinamine salt 2000g (4.96mol, 1.0eq), 2-chloropropene cyanide (7.44mol, 1.5eq) was added with potassium carbonate 684g (4.96mol, 1.0eq) and stirred at 20-30°C for 8h. Then the mixtrue was heated with dropwise 1132g (7.44mol, 1.5eq) of diazabicyclo at 50-60°C for 20h. After the reaction is finished and poured into water 30 L at RT. the solution was filtered, washed with water and recrystallized in ethanol to give a pale yellow solid, 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (702g 56%). |
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