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Cinitapride monotartrate is a 5-HT1A and 5-HT4 agonist. Cinitapride monotartrate is also a 5-HT2A and D2 antagonist. Cinitapride monotartrate can be used for the research of functional dyspepsia[1][2]. | [in vivo]
Cinitapride (intraperitoneal injection; 0.25-1 mg/kg; once) shows gastroprotective effetcs in gastric ulceration rat model[2]. | Animal Model: | Male Wistar rats with gastric ulceration[2] | | Dosage: | 0.25-1 mg/kg | | Administration: | Intraperitoneal injection; 0.25-1 mg/kg; once | | Result: | Reduced haemorrhagic lesions compared with the ulcerated control group.
Decreased the percentage of ulceration to 28.76% at the highest dose (1 mg/kg).
Attenuated the increase myeloperoxidase activity (p<0.05, p<0.01).
Increased GSH-px activity in the gastric mucosa.
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| [IC 50]
5-HT2 Receptor; 5-HT1 Receptor; 5-HT4 Receptor; D2 Receptor | [References]
[1] Du Y, et al. Efficacy and safety of cinitapride in the treatment of mild to moderate postprandial distress syndrome-predominant functional dyspepsia. J Clin Gastroenterol. 2014 Apr;48(4):328-35. DOI:10.1097/MCG.0000000000000033
[2] Alarcón de la Lastra C, et al. Effects of cinitapride on gastric ulceration and secretion in rats. Inflamm Res. 1998 Mar;47(3):131-6. DOI:10.1007/s000110050301
[3] Parthena MARTIN, et al. Compositions and methods for treating seizure disorders. Patent WO2018060732A2. |
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