| Hazard Information | Back Directory | [Description]
BDF 9148 is a Na(+)-channel modulator as well as a congener of DPI 201-106, and was found to increase the contractile force of guinea-pig atria and papillary muscles. | [Uses]
BDF 9148 is a sodium-channel activator with antiarrhythmic properties that produces a significant CAMP-independent positive inotropic effect in left ventricular myocardium from failing hearts. BDF 9148 is promising for research of myocardial failure[1]. | [References]
[1] Schwinger RH, et al. Evidence for a sustained effectiveness of sodium-channel activators in failing human myocardium. J Mol Cell Cardiol. 1991 Apr;23(4):461-71. DOI:10.1016/0022-2828(91)90170-q |
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