| Identification | Back Directory | [Name]
2(3H)-Benzoxazolone, 3-[(3-hydroxyphenyl)methyl]-5-methyl- | [CAS]
1208448-95-6 | [Synonyms]
MIF098
2(3H)-Benzoxazolone, 3-[(3-hydroxyphenyl)methyl]-5-methyl- | [Molecular Formula]
C15H13NO3 | [MOL File]
1208448-95-6.mol | [Molecular Weight]
255.27 |
| Chemical Properties | Back Directory | [Boiling point ]
466.0±55.0 °C(Predicted) | [density ]
1.342±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.81±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist. MIF098 inhibits proliferation, migration and fibrosis of pulmonary smooth muscle cells. MIF098 can be used for immunoinflammation-related disease research[1]. | [in vivo]
MIF098 (intraperitoneal injection, 40 mg/kg, once a day, 4 weeks) attenuates the process of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice[1].
| Animal Model: | Hypoxic male C57BL/6J mice[1] | | Dosage: | 40 mg/kg | | Administration: | Intraperitoneal injection; once a day; 4 weeks | | Result: | Reduced right ventricular systolic pressure (RVSP), percentage medial wall thickness, muscularization and right ventricle collagen deposition.
Decreased percentage of collagen fibers in pulmonary artery (PA).
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| [References]
[1] HuijingHuang, et al. The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLE. Int Immunopharmacol. 2019 Nov;76:105874. DOI:10.1016/j.intimp.2019.105874 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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