| Identification | Back Directory | [Name]
Threo-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | [CAS]
120924-80-3 | [Synonyms]
Aids007341
Aids-007341
Rac-(2R*,3R*)-2-(2,4-difluorophenyl)-3-(methylsulfonyl)-1-(1,2,4-triazol-1-yl)-2-butanol
1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-[(1R)-1-(methylsulfonyl)ethyl]-, (αR)-rel- | [Molecular Formula]
C13H15F2N3O3S | [MOL File]
120924-80-3.mol | [Molecular Weight]
331.34 |
| Hazard Information | Back Directory | [Uses]
SM-8668 is an effective orally active antifungal agent, with median effective doses (ED50) of 0.18, 3.7, and 5.9 mg/kg for systemic candidiasis, aspergillosis, and cryptococcosis in mice, respectively. Pharmacokinetic studies in mice and rats indicate that SM-8668 has a long half-life and a high total exposure. SM-8668 can be used in anti-infective research[1]. | [References]
[1] Tanio T, et al. In vivo efficacy of SM-8668 (Sch 39304), a new oral triazole antifungal agent. Antimicrob Agents Chemother. 1990 Jun;34(6):980-4. DOI:10.1128/AAC.34.6.980 |
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