| Identification | Back Directory | [Name]
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- | [CAS]
120964-45-6 | [Synonyms]
DZNepHCl
NSC 617989 HCl
DZNEP; NSC 617989
DZNep hydrochloride
3-deazaneplanocin A HCl
NSC 617989 hydrochloride
3-Deazaneplanocin hydrochloride
3-deazaneplanocin A (DZNeP) HCl
3-Deazaneplanocin A (hydrochloride)
3-deazaneplanocin A HCl (DZNep HCl)
3-Deazaneplanocin A (DZNep) hydrochloride
Histone Methyltransferase EZH2 Inhibitor, DZNep
3-Deazaneplanocin A hydrochloride
(DZNep hydrochloride
1H-Imidazo[4,5-c]pyridine, 3-cyclopentene-1,2-diol deriv.
DZNEP HYDROCHLORIDE;NSC 617989 HYDROCHLORIDE;3-DEAZANEPLANOCIN HYDROCHLORIDE
Histone Methyltransferase EZH2 Inhibitor, DZNep - CAS 120964-45-6 - Calbiochem
(1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride
(-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine hydrochloride
(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride (1:1)
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- USP/EP/BP
(-)-1-[(1R,4R,5S)-3-(HydroxyMethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aMinoiMidazo[4,5-c]pyridine hydrochloride DZNep hydrochloride | [Molecular Formula]
C12H15ClN4O3 | [MDL Number]
MFCD18782644 | [MOL File]
120964-45-6.mol | [Molecular Weight]
298.726 |
| Chemical Properties | Back Directory | [Melting point ]
168-169℃ | [storage temp. ]
-20°C | [solubility ]
H2O: ≥5mg/mL | [form ]
Tan solid | [color ]
white to beige | [Optical Rotation]
[α]/D -88 to -108°, c =0.1 in water | [Water Solubility ]
Soluble in water (10mM) | [InChI]
InChI=1/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H/t8-,10-,11+;/s3 | [InChIKey]
UNSKMHKAFPRFTI-FDKLLANESA-N | [SMILES]
C1[C@@H]([n]2c3ccnc(N)c3nc2)[C@H](O)[C@H](O)C=1CO.Cl |&1:1,12,14,r| |
| Hazard Information | Back Directory | [Uses]
3-Deazaneplanocin A is a a powerful inhibitor of S-adenosylhomocysteine hydrolase that has shown potent and selective in vitro and in vivo antiviral activities. | [General Description]
3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic?property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma. | [Biochem/physiol Actions]
3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2. | [target]
histone methyltransferase | [storage]
Store at -20°C |
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SYNTHENTA PVT LTD
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+91-7416102217 +91-7416102217 |
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www.synthenta.com |
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