| Identification | Back Directory | [Name]
Methyl 6-bromo-5-fluoropyridine-2-carboxylate | [CAS]
1210419-26-3 | [Synonyms]
uoropicoL
6-bromo-5-fL
methyl 6-bromo-5-fluoropicolinat
Methyl 6-bromo-5-fluoropicolinate
N'-(3,4-dichlorophenyl)ethane-1,6-diamine
Methyl 6-bromo-5-fluoropyridine-2-carboxylate
6-Bromo-5-fluoro-pyridine-2-carboxylic acid methyl ester
2-Pyridinecarboxylic acid, 6-bromo-5-fluoro-, methyl ester
Methyl 6-bromo-5-fluoropicolinate, 2-Bromo-3-fluoro-6-(methoxycarbonyl)pyridine | [Molecular Formula]
C7H5BrFNO2 | [MDL Number]
MFCD14698111 | [MOL File]
1210419-26-3.mol | [Molecular Weight]
234.02 |
| Chemical Properties | Back Directory | [Boiling point ]
275.5±35.0 °C(Predicted) | [density ]
1.660±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
solid | [pka]
-3.45±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Synthesis]
Synthesis of methyl 6-bromo-5-fluoro-pyridinecarboxylate: Concentrated sulfuric acid (4.2 eq.) was slowly added to a methanol (0.2 M) solution of 6-bromo-5-fluoro-2-pyridinecarboxylic acid (1.0 eq.) and the reaction mixture was stirred at room temperature. The progress of the reaction was monitored by LC/MS and the reaction was completed after about 2 hours. The reaction mixture was diluted with ethyl acetate and saturated aqueous sodium bicarbonate solution was added slowly to quench the reaction. The mixture was transferred to a partition funnel and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford methyl 6-bromo-5-fluoropyridinecarboxylate as a white solid (yield >99%). The product was characterized by LC/MS: m/z = 233.9/235.9 ([M+H]+), retention time Rt = 0.69 min. | [References]
[1] Patent: US2010/56576, 2010, A1. Location in patent: Page/Page column 48
[2] Patent: WO2012/4217, 2012, A1. Location in patent: Page/Page column 65-66
[3] Patent: US2012/225062, 2012, A1. Location in patent: Page/Page column 26; 27
[4] Patent: US2012/225061, 2012, A1. Location in patent: Page/Page column 22
[5] Patent: WO2013/175388, 2013, A1. Location in patent: Page/Page column 44 |
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