| Chemical Properties | Back Directory | [density ]
1.193±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 3.33 mg/mL (10.11 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
7.31±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GSK2556286 (GSK286) is an orally active inhibitor of M. tuberculosis. GSK2556286 inhibits growth within human macrophages (IC50 = 0.07 μM). GSK2556286 is effective against both multidrug-resistant (MDR) or extensively drug-resistant (XDR) and agent-sensitive (DS) M. tuberculosis. | [References]
[1] Nuermberger EL, et al. GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment. Antimicrob Agents Chemother. 2022 May 24:e0013222. DOI:10.1128/aac.00132-22 |
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