| Identification | Back Directory | [Name]
Oxycodegol | [CAS]
1211231-76-3 | [Synonyms]
NKTR-181
Oxycodegol
Loxicodegol
Morphinan-14-ol, 4,5-epoxy-6-(3,6,9,12,15,18-hexaoxanonadec-1-yloxy)-3-methoxy-17-methyl-, (5α,6α)- | [Molecular Formula]
C31H49NO10 | [MOL File]
1211231-76-3.mol | [Molecular Weight]
595.73 |
| Hazard Information | Back Directory | [Uses]
Loxicodegol (Oxycodegol) is a first-in-class, long-acting, orally active, and selective mu-opioid agonist with structural properties that reduce its rate of entry across the blood-brain barrier compared with traditional mu-opioid agonists[1][2]. | [References]
[1] Miyazaki T, et al. NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential. J Pharmacol Exp Ther. 2017;363(1):104-113. DOI:10.1124/jpet.117.243030
[2] Gudin J, et al. Long-term Safety and Tolerability of NKTR-181 in Patients with Moderate to Severe Chronic Low Back Pain or Chronic Noncancer Pain: A Phase 3 Multicenter, Open-Label, 52-Week Study (SUMMIT-08 LTS). Pain Med. 2020;21(7):1347-1356. DOI:10.1093/pm/pnz169 |
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