| Identification | Back Directory | [Name]
3-Piperidinecarboxylic acid, 1-[3-(2-chlorophenyl)-1-oxopropyl]-, ethyl ester | [CAS]
1211379-56-4 | [Synonyms]
INF195
3-Piperidinecarboxylic acid, 1-[3-(2-chlorophenyl)-1-oxopropyl]-, ethyl ester | [Molecular Formula]
C17H22ClNO3 | [MOL File]
1211379-56-4.mol | [Molecular Weight]
323.82 |
| Chemical Properties | Back Directory | [Boiling point ]
468.1±45.0 °C(predicted) | [density ]
1.190±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Viscous Liquid | [pka]
-1.64±0.40(predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC50 value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury[1]. | [IC 50]
IL-1β; NLRP3 | [References]
[1] Gastaldi S, et al. Novel NLRP3 inhibitor INF195: Low doses provide effective protection against myocardial ischemia/reperfusion injury. Vascul Pharmacol. 2024 Jun 17;156:107397. DOI:10.1016/j.vph.2024.107397 |
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