| Identification | Back Directory | [Name]
7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethyl- | [CAS]
1211443-61-6 | [Synonyms]
EOS-60967
Ribociclib-1
RIBOCICLIB INT
RIBOCICLIB INT3
(Chloro Amide Impurity)
Ribociclib Intermediate 3
Ribociclib Intermediate 4
Ribociclib Chloro Amide IMP
Ribociclib Chloro Amide Impurity
7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide
7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chlor
7H-Pyrrolo[2,3-dChemicalbook]pyriMidine-6-carboxaMide,2-chlor
2-Chloro-7-cyclopentyl-n,n-dimethyl-7h-pyrrolo[2,3d]pyrimidi...
2-chloro-7-cyclopentyl-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide
2-chloro-7-cyclopentyl-N,N-diMethyl-7H-pyrrolo[2,3-d]pyriMidine-6-arboxaMide
2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethy
2-chloro-7-cyclopentyl-N,N-diMethyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxaMide
2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrol o[2,3-d]pyrimidine-6-carboxamide
2-Chloro-7-cyclopentyl-n,n-dimethyl-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide4
2-Chloro-7-cyclopentyl-N, Ndimethyl-7H-pyrrolo{2,3-d}
pyrimidine-6-carboxylate
7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethyl-
2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide | [EINECS(EC#)]
808-234-2 | [Molecular Formula]
C14H17ClN4O | [MDL Number]
MFCD20527881 | [MOL File]
1211443-61-6.mol | [Molecular Weight]
292.764 |
| Chemical Properties | Back Directory | [density ]
1.40±0.1 g/cm3(Predicted) | [vapor pressure ]
0-0Pa at 20-25℃ | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
Solid:particulate/powder | [pka]
2.78±0.30(Predicted) | [Appearance]
Off-white to yellow Solid | [InChI]
InChI=1S/C14H17ClN4O/c1-18(2)13(20)11-7-9-8-16-14(15)17-12(9)19(11)10-5-3-4-6-10/h7-8,10H,3-6H2,1-2H3 | [InChIKey]
PMDDQOHZLBZUSO-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=C2C=C(C(N(C)C)=O)N(C3CCCC3)C2=N1 | [LogP]
2.4 at 20℃ and pH7 | [CAS DataBase Reference]
1211443-61-6 |
| Hazard Information | Back Directory | [Uses]
2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide belongs to pyrimidine derivatives,it is used in the synthesis of ribociclib intermediates. | [Synthesis]
To a three-necked flask was added 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-D]pyrimidine-6-carboxylic acid (26.57 g, 100 mmol) and N,N-dimethylformamide (133 mL), and the mixture was cooled to 0-5 °C under stirring. EDCI (23.00 g, 120 mmol) and a tetrahydrofuran solution of dimethylamine (2.0 M, 75 mL, 150 mmol) were then added. Triethylamine (20.24 g, 200 mmol) was added dropwise and the mixture was stirred at 20-25 °C for 6-8 hours. After completion of the reaction, the reaction mixture was extracted three times with ethyl acetate (133 mL) and the organic phases were combined. The organic phase was sequentially washed twice with water and once with brine (133 mL), dried with anhydrous sodium sulfate and concentrated. Finally, the target product 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (26.93 g, 92% yield) was purified by column chromatography in a mixed solvent of dichloromethane and methanol. | [References]
[1] Patent: CN106478641, 2017, A. Location in patent: Paragraph 0050; 0051; 0052
[2] Patent: WO2010/20675, 2010, A1. Location in patent: Page/Page column 89; 91 |
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