| Identification | Back Directory | [Name]
Boc-(+/-)-trans-2-aminocyclohexanol | [CAS]
121282-70-0 | [Synonyms]
1R,2R-Boc-2-aMinocyclohexanol
trans-N-Boc-2-aminocyclohexanol
tert-Butyl (trans-2-hydroxycyclohexyl)
tert-Butyl (1R,2R)-2-hydroxycyclohexyl
tert-butyl (2-hydroxycyclohexyl)carbaMate
Trans-tert-butyl 2-hydroxycyclohexyl)carbaMate
tert-butyl (1R,2R)-2-hydroxycyclohexylcarbamate
tert-Butyl (trans-2-hydroxycyclohexyl)carbaMate
tert-butyl N-[trans-2-hydroxycyclohexyl]carbamate
rel-tert-Butyl N-[(1R,2R)-2-hydroxycyclohexyl]carbamate
Carbamic acid,N-[(1R,2R)-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester,rel- | [Molecular Formula]
C11H21NO3 | [MOL File]
121282-70-0.mol | [Molecular Weight]
215.29 |
| Chemical Properties | Back Directory | [Boiling point ]
337.7±31.0 °C(Predicted) | [density ]
1.06±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
12.11±0.40(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1/C11H21NO3/c1-11(2,3)15-10(14)12-8-6-4-5-7-9(8)13/h8-9,13H,4-7H2,1-3H3,(H,12,14)/t8-,9-/s3 | [InChIKey]
XVROWZPERFUOCE-JQEWEITDNA-N | [SMILES]
C(OC(C)(C)C)(=O)N[C@@H]1CCCC[C@H]1O |&1:8,13,r| |
| Hazard Information | Back Directory | [Uses]
tert-Butyl (2-Hydroxycyclohexyl)carbamate is a reagent used in the preparation of N-aryl acetamides from the corresponding nitro compounds. | [Synthesis]
General procedure for the synthesis of trans-N-Boc-cyclohexylamino alcohols from the compounds (CAS: 764659-69-0): the product of part A (8.0 g, 26.2 mmol) was dissolved in a solvent mixture of cyclohexene (100 mL) and ethanol (150 mL), and palladium/carbon catalyst (2.0 g) was added. The reaction mixture was heated to reflux for 6 h. Upon completion of the reaction, the catalyst was removed by filtration through a Celite pad. The filtrate was concentrated to afford tert-butyl (1S,2S)-2-hydroxy-cyclohexyl-carbamate (5.7 g, 100% yield) as a white solid. Mass spectral analysis showed M/Z 216.2 ([M + H]+). | [References]
[1] Patent: WO2004/83174, 2004, A2. Location in patent: Page 172
[2] Patent: WO2005/87731, 2005, A1. Location in patent: Page/Page column 321
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 16, p. 4419 - 4427
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 119 - 132 |
|
| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
AllyChem Co., Ltd.
|
| Tel: |
0411-62313318 13942603642 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList677/0_EN.htm |
|