| Identification | Back Directory | [Name]
EPI 743 | [CAS]
1213269-98-7 | [Synonyms]
EPI 743
Vatiquinone
Vatiquinone (EPI743)
alpha-Tocotrienol quinone. ATQ3
2-[(3R,6E,10E)-3-Hydroxy-3,7,11,15-tetramethyl-6,10,14-hexadecatrien-1-yl]-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione
2,5-Cyclohexadiene-1,4-dione, 2-[(3R,6E,10E)-3-hydroxy-3,7,11,15-tetramethyl-6,10,14-hexadecatrien-1-yl]-3,5,6-trimethyl- | [Molecular Formula]
C29H44O3 | [MDL Number]
MFCD28963977 | [MOL File]
1213269-98-7.mol | [Molecular Weight]
440.658 |
| Chemical Properties | Back Directory | [Boiling point ]
565.6±39.0 °C(Predicted) | [density ]
0.978±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol:10.0(Max Conc. mg/mL);22.69(Max Conc. mM) | [form ]
Liquid | [pka]
14.88±0.29(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione[1][2]. | [Biological Activity]
Vatiquinone (EPI-743)a metabolite of a-tocotrienolis an orally available and highly potent analog of coenzyme Q10 th at modulates the activity of oxidoreductases including AD(P)H:quinone oxidoreductase 1resulting in increased cellular GSH concentration and improvement in redox status. Vatiquinone is an agent designated to tre at mitochondrial diseases. | [storage]
Store at -20°C | [References]
[1] Kouga T, et al. Japanese Leigh syndrome case treated with EPI-743. Brain Dev. 2018 Feb;40(2):145-149. Brain Dev. 2018 Feb;40(2):145-149. DOI:10.1016/j.braindev.2017.08.005
[2] Avula S, et al. Treatment of Mitochondrial Disorders. Curr Treat Options Neurol. 2014. 16:292.
[3] Kahn-Kirby AH, et al. Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy. PLoS One. 2019 Mar 28;14(3):e0214250. DOI:10.1371/journal.pone.0214250 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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