| Hazard Information | Back Directory | [Description]
AN3485 Hydrochloride is an inhibitor of TLR2-, TLR3-, TLR4- and TLR5-mediated TNF-α, IL-1β and IL-6. | [Uses]
AN-3485 hydrochloride is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM. | [IC 50]
TLR2; TLR3; TLR4; TLR5 | [References]
[1] Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344(2):436-46. DOI:10.1124/jpet.112.200030 |
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