| Identification | Back Directory | [Name]
5-BroMo-6-hydroxypicolinic acid | [CAS]
1214385-51-9 | [Synonyms]
5-BroMo-6-hydroxypicolinic acid
5-bromo-6-hydroxypyridine-2-carboxylic acid
5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylic acid
2-Pyridinecarboxylic acid, 5-bromo-1,6-dihydro-6-oxo- | [Molecular Formula]
C6H4BrNO3 | [MDL Number]
MFCD13185807 | [MOL File]
1214385-51-9.mol | [Molecular Weight]
218 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 5-bromo-6-hydroxypyridinecarboxylic acid from 6-hydroxypyridine-2-carboxylic acid: bromine (115 g, 720 mmol) was added dropwise to a suspension of 6-oxo-1,6-dihydropyridine-2-carboxylic acid (25 g, 180 mmol) in acetic acid (400 mL). The reaction mixture was heated to 80 °C and kept for 16 hours. Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was ground with tert-butyl methyl ether (200 mL) and subsequently filtered. The filter cake was washed with tert-butyl methyl ether (3 x 100 mL) to give a gray solid product. Yield: 39.0 g, 179 mmol, 99% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.03 (d, J = 7.3 Hz, 1H), 6.83 (d, J = 7.3 Hz, 1H). | [References]
[1] Patent: US2016/222007, 2016, A1. Location in patent: Paragraph 0354; 0355 |
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