| Identification | Back Directory | [Name]
YMYFRDZTZVZUPF-MNJXXUMNSA-N | [CAS]
1214726-89-2 | [Synonyms]
AS2521780
(AS 2521780
YMYFRDZTZVZUPF-MNJXXUMNSA-N | [Molecular Formula]
C30H41N7OS | [MDL Number]
MFCD28411711 | [MOL File]
1214726-89-2.mol | [Molecular Weight]
547.77 |
| Chemical Properties | Back Directory | [Boiling point ]
791.5±70.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
15.24±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
AS2521780 is a potent and selective PKCθ inhibitor. | [Uses]
AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM. | [in vivo]
AS2521780 significantly reduces paw swelling in a dose-dependent manner in a rat model of adjuvant-induced arthritis[1]. | [IC 50]
PKCθ: 0.48 nM (IC50); PKCε: 18 nM (IC50); PKCα: 160 nM (IC50); PKCδ: 160 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Fukahori H, et al. Effect of AS2521780, a novel PKCθ selective inhibitor, on T cell-mediated immunity. Eur J Pharmacol. 2014 Dec 15;745:217-22. DOI:10.1016/j.ejphar.2014.10.045 |
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