| Identification | Back Directory | [Name]
2,6-dichloro-N-(difluoromethyl)-4-[3-(1-methylpiperidin-4-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide | [CAS]
1215012-74-0 | [Synonyms]
DDD100097
DDD-100097
DDD 100097
2,6-dichloro-N-(difluoromethyl)-4-[3-(1-methylpiperidin-4-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide | [Molecular Formula]
C22H30Cl2F2N4O2S | [MDL Number]
MFCD28963935 | [MOL File]
1215012-74-0.mol | [Molecular Weight]
523.467 |
| Hazard Information | Back Directory | [Description]
DDD100097 is an inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT) with markedly improved blood-brain barrier permeability. | [Uses]
DDD100097 is a potent acyltransferase (TbNMT) inhibitor with an IC50 value of 2 nM. DDD100097 can significantly improve blood-brain barrier permeability. DDD100097 can be used in the study of African trypanosomiasis[1]. | [References]
[1] Brand S, et al. Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis. J Med Chem. 2014 Dec 11;57(23):9855-69. DOI:10.1021/jm500809c |
|
|