| Identification | Back Directory | [Name]
GLPG0492 (R enantiomer) | [CAS]
1215085-93-0 | [Synonyms]
GLPG0492 (R enantiomer)
GLPG-0492 R enantiomer
(GLPG0492 R enantiomer)
Benzonitrile, 4-[(4R)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)- | [Molecular Formula]
C19H14F3N3O3 | [MOL File]
1215085-93-0.mol | [Molecular Weight]
389.33 |
| Chemical Properties | Back Directory | [Boiling point ]
544.0±60.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.50±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, which is a novel selective androgen receptor modulator. | [storage]
Store at -20°C | [References]
[1] Nique F, et al. Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator. J Med Chem. 2012 Oct 11;55(19):8236-47. DOI:10.1021/jm300281x
[2] Cozzoli A, et al. GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy. Pharmacol Res. 2013 Jun;72:9-24. DOI:10.1016/j.phrs.2013.03.003
[3] Blanqué R, et al. Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization. BMC Musculoskelet Disord. 2014 Sep 3;15:291. DOI:10.1186/1471-2474-15-291 |
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