| Identification | Back Directory | [Name]
Fexofenadine-d10 Hydrochloride | [CAS]
1215821-44-5 | [Synonyms]
RRJFVPUCXDGFJB-MQHVTZQPSA-N
Fexofenadine-d10 Hydrochloride
[2H10]-Fexofenadine hydrochloride | [Molecular Formula]
C32H29D10NO4.ClH | [MOL File]
1215821-44-5.mol | [Molecular Weight]
548.18 |
| Chemical Properties | Back Directory | [Melting point ]
150-155°C | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
Fexofenadine-d10 is intended for use as an internal standard for the quantification of fexofenadine by GC- or LC-MS. Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM). It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine . Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells. Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; ). | [Uses]
Fexofenadine-d10 Hydrochloride is the labeled analogue of Fexofenadine Hydrochloride (F322490), the active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist. | [IC 50]
H1 Receptor | [References]
[1] WOODWARD P J K. Pharmacology of antihistamines[J]. Journal of Allergy and Clinical Immunology, 1990, 86 4: Pages 606-612. DOI: 10.1016/s0091-6749(05)80224-6
[2] W S LAI. Efficacy of fexofenadine in isolated rat tracheas.[J]. Rhinology, 2013, 51 4: 376-380. DOI: 10.4193/rhino12.213
[3] SEONG-JOON KOH. Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in mice.[J]. Journal of Pharmacology and Experimental Therapeutics, 2015, 352 3: 455-461. DOI: 10.1124/jpet.114.217844 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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