| Identification | Back Directory | [Name]
Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- | [CAS]
1216074-15-5 | [Synonyms]
5-HT2CR agonist 1
Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- | [Molecular Formula]
C13H14ClNO | [MOL File]
1216074-15-5.mol | [Molecular Weight]
235.71 |
| Hazard Information | Back Directory | [Uses]
5-HT2CR agonist 1 (compound 8), a 7-chloro analogue, is a selective 5-HT2CR partial agonist (Emax=71.09%) with an EC50 value of 121.5 nM and no observed activity toward 5-HT2AR or 5-HT2BR. 5-HT2CR agonist 1 exhibits no recruitment activity for β-arrestin and shows low inhibition of hERG at 10 μM[1]. | [IC 50]
5-HT2C Receptor: 121.5 nM (EC50) | [References]
[1] Guangqian Jiang, et al Identification of Spiro[chromene-2,4′-piperidine]s as Potent, Selective, and Gq-Biased 5-HT2C Receptor Partial Agonists. ACS Med. Chem. Lett. December 18, 2023. |
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Biorbyt Ltd.
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