ChemicalBook--->CAS DataBase List--->1216074-15-5

1216074-15-5

Request For Quotation
1216074-15-5 Structure

1216074-15-5 Structure
IdentificationBack Directory
[Name]

Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro-
[CAS]

1216074-15-5
[Synonyms]

5-HT2CR agonist 1
Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro-
[Molecular Formula]

C13H14ClNO
[MOL File]

1216074-15-5.mol
[Molecular Weight]

235.71
Chemical PropertiesBack Directory
[Boiling point ]

367.9±42.0 °C(Predicted)
[density ]

1.26±0.1 g/cm3(Predicted)
[pka]

9.59±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

5-HT2CR agonist 1 (compound 8), a 7-chloro analogue, is a selective 5-HT2CR partial agonist (Emax=71.09%) with an EC50 value of 121.5 nM and no observed activity toward 5-HT2AR or 5-HT2BR. 5-HT2CR agonist 1 exhibits no recruitment activity for β-arrestin and shows low inhibition of hERG at 10 μM[1].
[IC 50]

5-HT2C Receptor: 121.5 nM (EC50)
[References]

[1] Guangqian Jiang, et al Identification of Spiro[chromene-2,4′-piperidine]s as Potent, Selective, and Gq-Biased 5-HT2C Receptor Partial Agonists. ACS Med. Chem. Lett. December 18, 2023.
1216074-15-5 suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Website: www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: Biorbyt Ltd.  
Tel: +44 (0)1223 859 353
Website: http://www.biorbyt.com
Tags:1216074-15-5 Related Product Information