| Identification | Back Directory | [Name]
1-Piperazinecarbothioamide, 4-(1,3-benzodioxol-5-ylmethyl)-N-(3-ethoxypropyl)-, ethanedioate (1:1) | [CAS]
1216676-34-4 | [Synonyms]
GJ071
GJ-071
GJ 071
GJ071 oxalate
1-Piperazinecarbothioamide, 4-(1,3-benzodioxol-5-ylmethyl)-N-(3-ethoxypropyl)-, ethanedioate (1:1) | [Molecular Formula]
C20H29N3O7S | [MOL File]
1216676-34-4.mol | [Molecular Weight]
455.53 |
| Hazard Information | Back Directory | [Description]
GJ-071 is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into nascent polypeptide. | [Uses]
GJ071 oxalate induces ATM kinase activity in ataxia telangiectasia (A-T) cells carrying homozygous TGA or TAG stop codons[1]. | [References]
[1] Du L, et al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60. DOI:10.1038/mt.2013.150 |
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