| Identification | Back Directory | [Name]
Amiodarone-D4 HCl | [CAS]
1216715-80-8 | [Synonyms]
Amiodarone hydrochloride salt
[2H4]-Amiodarone Hydrochloride
Amiodarone-D4 hydrochloride solution
AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE)
(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride
Amiodarone D4 HydrochlorideQ: What is
Amiodarone D4 Hydrochloride Q: What is the CAS Number of
Amiodarone D4 Hydrochloride Q: What is the storage condition of
Amiodarone D4 Hydrochloride Q: What are the applications of
Amiodarone D4 Hydrochloride | [EINECS(EC#)]
806-400-9 | [Molecular Formula]
C25H30ClI2NO3 | [MDL Number]
MFCD08064189 | [MOL File]
1216715-80-8.mol | [Molecular Weight]
681.78 |
| Chemical Properties | Back Directory | [Fp ]
9℃ | [storage temp. ]
-20°C | [solubility ]
DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml | [form ]
A solid | [color ]
White to off-white | [Stability:]
Very Hygroscopic | [Major Application]
clinical testing | [InChIKey]
ITPDYQOUSLNIHG-MMJSDMDPSA-N | [SMILES]
Cl.[2H]C([2H])(Oc1c(I)cc(cc1I)C(=O)c2c(CCCC)oc3ccccc23)C([2H])([2H])N(CC)CC |
| Safety Data | Back Directory | [Hazard Codes ]
F,T | [Risk Statements ]
11-23/24/25-39/23/24/25 | [Safety Statements ]
7-16-36/37-45 | [RIDADR ]
UN1230 - class 3 - PG 2 - Methanol, solution | [WGK Germany ]
1 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| Hazard Information | Back Directory | [Description]
Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations. | [Uses]
A Labelled non-selective ion channel blocker. Antiarrhythmic (class III). | [General Description]
A Certified Spiking Solution?and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone?, Cordarone?, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range. | [storage]
Store at -20°C | [References]
[1] T. J. CAMPBELL K. M W. Therapeutic drug monitoring: antiarrhythmic drugs[J]. British journal of clinical pharmacology, 2003, 46 4: 307-319. DOI: 10.1046/j.1365-2125.1998.t01-1-00768.x
[2] NANDITA SINHA Srikanta S. Predicting hERG activities of compounds from their 3D structures: Development and evaluation of a global descriptors based QSAR model[J]. European Journal of Medicinal Chemistry, 2011, 46 2: Pages 618-630. DOI: 10.1016/j.ejmech.2010.11.042
[3] CHRISTIAN LAGGNER. Discovery of High-Affinity Ligands of σ1 Receptor, ERG2, and Emopamil Binding Protein by Pharmacophore Modeling and Virtual Screening[J]. Journal of Medicinal Chemistry, 2005, 48 15: 4754-4764. DOI: 10.1021/jm049073+
[4] BO CARLSSON. Synthesis and Preliminary Characterization of a Novel Antiarrhythmic Compound (KB130015) with an Improved Toxicity Profile Compared with Amiodarone[J]. Journal of Medicinal Chemistry, 2002, 45 3: 623-630. DOI: 10.1021/jm001126+
[5] THOMAS M POLASEK. Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitro.[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 311 3: 996-1007. DOI: 10.1124/jpet.104.071803 |
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