| Identification | Back Directory | [Name]
2-(5-fluoropentyl)-2-MethylMalonic acid | [CAS]
1216897-16-3 | [Synonyms]
ML-10
2-(5-fluoropentyl)-2-MethylMalonic acid
Propanedioic acid,2-(5-fluoropentyl)-2-methy-
Propanedioic acid, 2-(5-fluoropentyl)-2-methyl- | [Molecular Formula]
C9H15FO4 | [MDL Number]
MFCD19443211 | [MOL File]
1216897-16-3.mol | [Molecular Weight]
206.211 |
| Hazard Information | Back Directory | [Uses]
ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential[1]. | [References]
[1] Cohen A, et al. From the Gla domain to a novel small-molecule detector of apoptosis. Cell Res. 2009 May;19(5):625-37. DOI:10.1038/cr.2009.17 |
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